The reference site for Mefenamic

Mefenamic acid is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs, and is used to treat mild to moderate pain, including menstrual pain, and is sometimes used to prevent migraines associated with menstruation.

WHAT IS Mefenamic?

Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. It is also prescribed as an antipyretic drug for oral administration.

Mefenamic acid decreases inflammation (swelling) and uterine contractions by a still unknown mechanism. However it is thought to be related to the inhibition of prostaglandin synthesis.

Since hepatic metabolism plays a significant role in mefenamic acid elimination, patients with known liver deficiency may be prescribed lower doses. Kidney deficiency may also cause accumulation of the drug and its metabolites in the excretory system. Therefore patients suffering from renal conditions should not be prescribed mefenamic acid.

This medication is commercially available as Ponstel®.

 

Brand Name(s): Ponstel
CAS nº: 61-68-7
(me Fe NAM ik)

 

Product Info

The sections below will provide you with more specific information and guidelines related to mefenamic and its correct use. Please read them carefully.

FDA Information

Mefenamic was approved by the FDA in March 1967. A prescription is required for this medicine.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain, and also prescribed as an antipyretic drug for oral administration.

Mefenamic acid decreases inflammation (swelling) and uterine contractions by a still unknown mechanism. However it is thought to be related to the inhibition of prostaglandin synthesis.

Since hepatic metabolism plays a significant role in mefenamic acid elimination, patients with known liver deficiency may be prescribed lower doses. Kidney deficiency may also cause accumulation of the drug and its metabolites in the excretory system. Therefore patients suffering from renal conditions should not be prescribed mefenamic acid.

Other uses for this medicine

This medication has not been approved for any alternative uses other than those mentioned in the product information section.

Dosage and using this medicine

Mefenamic acid comes as an orally-administered capsule.

Take mefenamic acid exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Each dose should be taken with a full glass of water, and with milk, food, or an antacid to lessen stomach upset.

Do not take mefenamic acid for longer than 1 week without first talking to your doctor. It is intended for short-term use only.

What special precautions should I follow?

BEFORE TAKING MEFENAMIC:

Tell your doctor if you have an allergy to aspirin or any other NSAIDs, an ulcer or bleeding in your stomach, have liver or kidney disease, a coagulation (bleeding) disorder, congestive heart failure, fluid retention, heart disease or high blood pressure. You may not be able to take mefenamic acid, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Other prescription and over-the-counter drugs may interact with mefenamic acid. Talk to your doctor before taking mefenamic acid if you are taking any of the following drugs: another nonsteroidal anti-inflammatory drug (NSAID) such as ketoprofen (Orudis®, Orudis KT®, Oruvail®), naproxen (Naprosyn®, Aleve®, Anaprox®), diclofenac (Voltaren®, Cataflam®), etodolac (Lodine®), fenoprofen (Nalfon®), flurbiprofen (Ansaid®), indomethacin (Indocin®), ketorolac (Toradol®), nabumetone (Relafen®), oxaprozin (Daypro®), piroxicam (Feldene®), sulindac (Clinoril®), or tolmetin (Tolectin®); aspirin or another salicylate (form of aspirin) such as salsalate (Disalcid®), choline salicylate, and magnesium salicylate; a diuretic (water pill) such as hydrochlorothiazide (HCTZ®, HydroDiuril®, others), chlorothiazide (Diuril®, others), chlorthalidone (Thalitone®), bumetanide (Bumex®), ethacrynic acid (Edecrin®), furosemide (Lasix®), spironolactone (Aldactone®), and amiloride (Midamor®); an anticoagulant such as warfarin (Coumadin®); a steroid such as prednisone (Deltasone®); an oral diabetes medication such as glipizide (Glucotrol®) or glyburide (Micronase®, Diabeta®); or lithium (Eskalith®, Lithobid®, others). Talk to your doctor before taking mefenamic acid if you are taking any other medicines, especially any of the ones listed above.

Mefenamic acid is in the FDA pregnancy category C. This means that it is not known whether it will be harmful to an unborn baby. Mefenamic acid should not be taken late in pregnancy (the third trimester) because a similar drug is known to affect the baby’s heart. Do not take mefenamic acid without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Furthermore, mefenamic acid passes into breast milk and may affect a nursing baby. Do not take this medicine without first talking to your doctor if you are breast-feeding a baby.

Avoid prolonged exposure to sunlight. Mefenamic acid may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

Additionally, please note that if you drink more than three alcoholic beverages a day, mefenamic acid may increase the risk of stomach bleeding.

What should I do if I forget a dose?

Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose.

Do not take a double dose of this medication.

What side effects can this medication cause?

If you experience any of the following serious side effects, stop taking mefenamic acid and seek medical treatment or contact your doctor immediately:

an allergic reaction (difficulty breathing, closing of the throat, swelling of the lips, tongue, or face, or hives)
muscle cramps, numbness, or tingling
ulcers (open sores) in the mouth
rapid weight gain (fluid retention)
seizures
black, bloody, or tarry stools
blood in urine or vomit
decreased hearing or ringing in the ears
yellowing of the skin or eyes (jaundice)
abdominal cramping, indigestion, or heartburn

Other, less serious side effects may be more likely to occur. Continue to take mefenamic acid and talk to your doctor if you experience:

dizziness or headache
nausea, gaseousness, diarrhea, or constipation
depression
fatigue or weakness
dry mouth
irregular menstrual periods

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

What storage conditions are needed for this medicine?

Please keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

Remember to throw away any medication that is outdated or no longer needed, and talk to your pharmacist about the proper disposal of your medication.

In case of an emergency/overdose

In the case of an overdose, call your local poison control center on 1-800-222-1222. However, if the victim has collapsed or is not breathing, please call the local emergency services immediately on 911.

Symptoms of overdose may include:

nausea
vomiting
stomach pain
dizziness
drowsiness
headache
ringing in the ears
blurred vision
seizures
sweating
numbness
tingling
little or no urine production
slow breathing

Product Images

PICTURES OF MEFENAMIC PILLS

Below you will find images and specific information on the principal types of mefenamic that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for patients taking this medication and should never be used to substitute professional medical advice that can be provided by a qualified physician or family doctor.

Name: PONSTEL®
Strength(s): 250 MG
Imprint: FHPC 400 | PONSTEL
Manufacturer: FIRST HORIZON PHARM.
Distributor: SCIELE PHARMACEUTICALS

Name: PONSTEL®
Strength(s): 250 MG
Imprint: RD 540 | PONSTEL
Manufacturer: PD-RX PHARM.

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